![.](/dam/jcr:a32ebdf7-4e35-4dca-b21b-1e06ee402d9a/hero-brain-smoldering-image.gif)
ONCE SPARKED,
SMOLDERING
NEUROINFLAMMATION
IS DESTRUCTIVE1,2
Beginning early in multiple sclerosis (MS), smoldering neuroinflammation can be largely unseen and lead to disability accumulation.1,3 But there is hope.
![.](/.imaging/webp/sanofi-platform/img-w620/dam/smolderingms-com/home/multiple-sclerosis-ms-unseen-pathway-icon.png/jcr:content/multiple-sclerosis-ms-unseen-pathway-icon.png)
The Unseen Pathway
Smoldering neuroinflammation: Thought to be a driver of disability accumulation3
![.](/.imaging/webp/sanofi-platform/img-w620/dam/smolderingms-com/home/smoldering-neuroinflammation-ms-icon.png/jcr:content/smoldering-neuroinflammation-ms-icon.png)
Smoldering Neuroinflammation
The impact of disability accumulation on your patients
![.](/.imaging/webp/sanofi-platform/img-w620/dam/smolderingms-com/home/management-multiple-sclerosis-both-pathways-icon.png/jcr:content/management-multiple-sclerosis-both-pathways-icon.png)
Stay Connected
Receive updates on the evolving conversations around MS
References:
- Cree BAC, Hollenbach JA, Bove R, et al; University of California, San Francisco MS-Epic Team. Silent progression in disease activity-free relapsing multiple sclerosis. Ann Neurol. 2019;85(5):653-666.
- Ziemssen T, Derfuss T, de Stefano N, et al. Optimizing treatment success in multiple sclerosis. J Neurol. 2016;263(6):1053-1065.
- Giovannoni G, Popescu V, Wuerfel J, et al. Smouldering multiple sclerosis: the ‘real MS’. Ther Adv Neurol Disord. 2022;15:17562864211066751. doi:10.1177/17562864211066751